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The GUO group focuses the research interest
on supramolecular biomedical materials. Supramolecular chemistry refers to the
chemistry based on intermolecular non-covalent interactions and studies the
recognition and assembly behavior between two or more molecules. We apply the
fundamental principles of supramolecular chemistry to create enhanced
diagnostics, therapeutics and theranostics. The central theme of our group is
the macrocyclic receptor calixarene, which imparts intriguing recognition and
assembly features after subtle modifications. Research in the group involves an
interdisciplinary mix of organic synthesis, supramolecular physical chemistry,
bio-sensing/imaging, and nanomedicine.
The GUO group takes advantage of molecular
recognition and self-assembly of calixarenes to engineer new smart biomaterials
to achieve precision medicine. Ongoing projects within the laboratory include:
