2025-Guo's Lab

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Achievements

2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 & Before

246

Enhanced Antitumor Efficacy and Reduced Myelosuppression by a Supramolecular Complex Composed of Azocalix[4]arene and Sunitinib, Jing Liu^#, Fangqian Yin^#, Yanbin Ren, Mengqiong Ming, Houhuan Xie, Xin Cai, Juan-Juan Li*, Dong-Sheng Guo*, and Ke-Rang Wang*, J. Med. Chem., 2025, DOI: 10.1021/acs.jmedchem.5c02487.

245

Ultrahigh-Affinity 1:1 and 1:2 Molecular Recognition in Water by a Rim-Carboxylated Chiral Corral[4]BINOL, Li-Bo Jing, Ruiguo Wang, Rong Fu, Hui-Tao Zheng, Jin-Lei Zhou, Qing-Yu Zhao, Zi-Hang Song, Dong-Sheng Guo and Kang Cai*, Sci. China Chem., 2025, DOI: 10.1007/s11426-025-3065-2.

244

The rise and promise of macrocyclic hosts in biomedicine, Yu-Chen Pan, Jia-Xuan Li, Dong-Sheng Guo*, ACS Cent. Sci., 2025, DOI: 10.1021/acscentsci.5c00891.

243

Chiral macrocycles forming high-affinity host-guest homoternary complexes for chiral discrimination and amplified circularly polarized luminescence, Rong Fu, Fang-Yuan Chen, Le Dai, Dai-Yuan Li, Qing-Yu Zhao, Si-Dan Guo, Zi-Hang Song, Li-Bo Jing, Heng Wang, Xiaopeng Li, Dong-Sheng Guo, Kang Cai*, Nat. Commun., 2025, 16, 9718.

242

A Single-Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer’s Disease via Intranasal Administration, Jian-Mei Gao^#, Wen-Bo Li^#, Na-Na Chen^#, Yang Yi, Ze-Han Wang, Xian Chen, Yang-Yang Zhao, Ze-Li Yuan, Jie Gao, Yu-Chen Pan, Dong-Sheng Guo* and Qi-Hai Gong*, Adv. Sci., 2025, DOI: 10.1002/advs.202511611.

241

Corral[n]bicarbazoles: Redox-active Chiral Macrocycles for Air-stable Radical Cations Formation and Guest Capture/Release, Ruiguo Wang^#, Han Han^#*, Li-Bo Jing, Peng-Yao Shen, Xiao, Xiao, Jia-Ying Deng, Qi Zhang, Haiting Di, Dong-Sheng Guo, Kang Cai*, Angew. Chem. Int. Ed., 2025, 64, e202511366.

240

Architecting X-Aggregates as Charge Transport Pathways to Enhance Photocatalytic Activity of Metal–Organic Frameworks, Ru-Yi Li^#, Wen-Ting Li^#, Han-Fei Fu, Fang-Yuan Chen, Xiu-Zhen Wang, Wei-Yan Chen, Yue Li*, and Dong-Sheng Guo, Small, 2025, 21, 2505216.

239

Multiple Host-Guest Interactions in Metal-Organic Frameworks Constructed by Inverted Calix[4]arenes, Zongsu Han^#, Kun-Yu Wang^#, Yifan Guo, Ze-Han Wang, Rong-Ran Liang, Yihao Yang, Jiatong Huo, Dong-Sheng Guo* and Hong-Cai Zhou*, J. Am. Chem. Soc., 2025, 147, 25162–25166.

238

Highly Sensitive, Specific and Fast Fluorescent Sensing of Amphetamine via Structural Regulation, Sifan Cao, Yuan Liu*, Yanan Guo, Baiyi Zu, Fei Yan, Dong-Sheng Guo*, and Xincun Dou*, ACS Sens., 2025, 10, 1998–2006.

237

Rapid Detection of Zeranol Contamination in Cereals Using a Quaternary Ammonium-Functionalized Terphen[3]arene-Based Optical Sensor, Danni Wang^#, Mengyu Ye^#, Huijuan Yu, Kejing Niu, Chunju Li, Dong-Sheng Guo*, and Yuefei Wang*, Foods, 2025, 14, 863.

236

Macrocycle-containing metal-organic frameworks in adsorption and related applications, Hui-Qing Zhao, Yue Li*, Chunju Li* and Dong-Sheng Guo*, J. Mater. Chem. A, 2025, 13, 23354-23376.

235

Ophthalmic formulation of methotrexate: a strategy of using the self-assembled LacAC4A nanoparticles for non-invasive drug delivery to the ocular posterior segment, Xiao-Yun Hou^#, Xiao-Ling Zhang^#, An-Kang Ying^#, Yu-Xin Yue, Tao Yang, Dong-Sheng Guo & Zhi-Qing Li*, Drug Delivery, 2025, 32, 2509962.

234

Macrocycle-Engineered Liposomes for Combating Bacterial Biofilm Infections, Tian-Xing Zhang^#*, Shiyu Peng^#, Shu-Xin Zhang^#, Yutong Xue, Linzhu Su, Fang-Yuan Chen, Jie Gao, Qingxiang Guo, Jianfeng Liu*, Fan Huang*, and Dong-Sheng Guo*, Chem. Eng. J., 2025, 518, 164500.

233

Hypoxia-sensitive macrocycle inclusion complexes for targeted protein degradation, Jiachan Lin^#, Wenyan Wang^#, An-Kang Ying^#, Zirui Chen, Dan Zhang, Chendi Ding, Xiaowei Zeng*, Dong-Sheng Guo* and Hongzhong Chen*, J. Control. Release, 2025, 384, 113921.

232

Single-molecule Macrocyclic Carrier Overcomes the Direct Transmembrane of Medium-sized Cargoes, Xiaoxue Hou, Xin-Yue Hu*, Yang Wang, Huan-Yu Wang, Yu-Chen Pan, Jie Chen, Juan-Juan Li, Ze-Han Wang, Fan Huang*, Jianfeng Liu*, Dong-Sheng Guo*, J. Am. Chem. Soc., 2025, 147, 20919-20929.

231

Acid-tolerant and hypoxia-responsive drug delivery system based on sulphobetaine-modified azocalix[4]arene for treating ulcerative colitis, Jing Liu^#, Juan-Juan Li^#, Hai-Qing Li, Meiqi Yang, Kai Zhang, Fangqian Yin,Yanbin Ren, Mengqiong Ming, Dong-Sheng Guo* and Ke-Rang Wang*, Nano Today, 2025, 64, 102801.

230

α-Synuclein targeted therapy with multiple pathological improvement for Parkinson's disease by macrocyclic amphiphile nanomedicine, Jian-Mei Gao^#, Wen-Bo Li^#, Yang Yi, Jia-Jia Wei, Miao-Xian Gong, Bin-Bin Pan, Xun-Cheng Su, Yu-Chen Pan*, Dong-Sheng Guo* and Qi-Hai Gong*, Biomaterials, 2025, 322, 123378.

229

Ultrahigh-Affinity Molecular Recognition in Water and Biomedical Applications, Fang-Yuan Chen^#, Rong Fu^#, Zhihao Gong, Chunju Li*, Dong-Sheng Guo*, and Kang Cai*, Angew. Chem. Int. Ed., 2025, 64, e202500916.

228

Integrating Proteolysis-Targeting Chimeras (PROTACs) with Delivery Systems for More Efficient and Precise Targeted Protein Degradation, Jiachan Lin, Zirui Chen, Dan Zhang, Nan Zhang, Hongzhong Chen*, and Dong-Sheng Guo*, Macromol. Rapid Commun., 2025, 46, 2401051.

227

Tubular Chiral Molecular Carbon Imides, Ruiguo Wang, Li-Bo Jing, Jia-Ying Deng, Han Han, Rong Fu, Fang-Yuan Chen, Dong-Sheng Guo, Kang Cai*, CCS Chem., 2025, DOI: 10.31635/ccschem.025.202505572.

226

Controllable Ultrahigh-Affinity Molecular Recognition, Fang-Yuan Chen^#, Han-Fang Zhang^#, Kang Cai* and Dong-Sheng Guo*, Supramol. Mater., 2025, 4, 100101.

225

High-affinity 1:2 recognition based on naphthyl-azocalix[4]arene and its application as a cleavable noncovalent connector in constructing responsive supramolecular polymeric materials, Shun-Yu Yao^#, An-Kang Ying^#, Wen-Chao Geng, Fang-Yuan Chen, Xin-Yue Hu, Kang Cai*, Dong-Sheng Guo*, Chem. Sci., 2025, 16, 7066-7076.

224

A Supramolecular Biofilm Disruptor Based on Cationic Macrocyclic Amphiphiles to Eradicate Bacterial Biofilm-Associated Infections, Shiyu Peng^#, Linzhu Su^#,*, Er-Wei Zhang, Xiaoxue Hou, Qingxiang Guo, Ning Zhu, Tian-Xing Zhang*, Dong-Sheng Guo*, Jianfeng Liu* and Fan Huang*, Chem. Eng. J., 2025, 508, 160905.

223

Chiral Covalent Organic Cages: Construction and Chiral Functions, Si-Dan Guo, Tianyu Jiao, Dong-Sheng Guo*, and Kang Cai*, Smart Molecules, 2025, 3, e20240038.

222

Fluorescent discrimination for snake venom via a dual-mode supramolecular sensor array, Han-Wen Tian, Jia-Hong Tian, Xin-Yue Hu*, and Dong-Sheng Guo*, Pure. Appl. Chem., 2025, DOI: 10.1515/pac-2024-0320.

221

Vesicle-Encapsulated Chemosensing Ensembles Allow Monitoring of Transmembrane Uptake Coupled with Enzymatic Reactions, Ruixue Jiang, Mohamed Nilam, Claudio Piselli, Mathias Winterhalter, Dong-Sheng Guo, Sin-Yi Yu, Andreas Hennig*, Werner M. Nau*, Angew. Chem. Int. Ed., 2025, 64, e202425157.

220

Engineered hypoxia-responsive albumin nanoparticles mediating mitophagy regulation for cancer therapy, Wenyan Wang^#, Shun-Yu Yao^#, Jingjing Luo, Chendi Ding, Qili Huang, Yao Yang, Zhaoqing Shi, Jiachan Lin, Yu-Chen Pan, Xiaowei Zeng*, Dong-Sheng Guo*, Hongzhong Chen*, Nat. Commun., 2025, 16, 596.

219

Macrocycle-based differential sensing: design strategies and applications, Jia-Hong Tian, Zhe Zheng, Yu-Chen Pan*, Yuefei Wang*, and Dong-Sheng Guo*, Responsive Mater., 2025, 3, e20240036.

218

A FRET Autophagy Imaging Platform by Macrocyclic Amphiphile, Ze-Tao Jiang^#, Jie Chen^#, Fang-Yuan Chen^#, Yuan-Qiu Cheng, Shun-Yu Yao, Rong Ma, Wen-Bo Li, Hongzhong Chen*, and Dong-Sheng Guo*, Angew. Chem. Int. Ed., 2025, 64, e202420793.

217

Enantiopure Macrocycles Based on Tröger's Base and Diphenyl Maleimide Exhibiting Strong Chiral Emission and Host-guest Properties, Zi-Hang Song, Yi-Fan Ma, Han Han, Dai-Yuan Li, Rong Fu, Qing-Yu Zhao, Ruiguo Wang, Dong-Sheng Guo*, Kang Cai*, Chem. Eur. J., 2025, 31, e202403271.

216

Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria, Jia-Hong Tian^#, Siyuan Huang^#, Ze-Han Wang, Juan-Juan Li, Xianhui Song, Ze-Tao Jiang, Bing-Sen Shi, Ying-Ying Zhao, Hui-Yan Zhang, Ke-Rang Wang, Xin-Yue Hu*, Xinge Zhang*, and Dong-Sheng Guo*, Nat. Commun., 2025, 16, 1016.

215

Assembly enhanced recognition: A biomimetic pathway to achieve ultrahigh affinities, Fang-Yuan Chen, Wen-Chao Geng, Meng-Meng Chen, Rong Fu, Han Han, Zhan-Zhan Zhang, Wen-Bo Li, Yuan-Qiu Cheng, Juan-Juan Li, J. Fraser Stoddart*, Kang Cai* and Dong-Sheng Guo*, Proc. Natl. Acad. Sci. U.S.A., 2025, 122, e2414253122.

214

Enhanced Subacute Ischemic Stroke Treatment via Multistage Drug Delivery System Design for Combination Therapy, Xihan Xu^#, Juan-Juan Li^#, Jiamin Li^#, Hui-Yan Zhang, Yilin Qi, Bing-Sen Shi, Tianqi Li, Shan-Shan Su, Weitao Zhao, Chang Chen, Zhongying Gong, Huiyu Liu*, Ke-Rang Wang*, Dong-Sheng Guo* and Xue Xue*, Sci China Chem, 2025, 68, 3162–3174.

213

Broad-Spectrum Detoxification of Snake Venoms with Supramolecular Materials Integrated via Molecular Recognition and Coassembly, Meng-Meng Chen, Han-Wen Tian, Yuan-Qiu Cheng, Yu-Xin Yue, Yu-Chen Pan*, and Dong-Sheng Guo*, Adv. Healthc. Mater., 2025, 14, 2402732.

212

Ligand-Insertion Strategy for Constructing 2D Conjugated Metal-Organic Framework with Large Pore Size for Electrochemical Analytics, Xiu-Zhen Wang, Yue Chen, Xiao-Min Cao, Ru-Yi Li, Wei-Yan Chen, Yue Li*, and Dong-Sheng Guo, Angew. Chem. Int. Ed., 2025, 64, e202413115.

211

A Study of Chiral Biomedical Effects based on Macrocyclic Carriers, Ze-Han Wang^#, Yuan-Qiu Cheng^#, Wen-Bo Li, Meng-Meng Chen, Shu-Xin Zhang, Yu-Chen Pan*, Dong-Sheng Guo*, CCS Chem., 2025, 7, 2121–2136.

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